This guide reflects the current practice of The National Health Service (NHS) gender clinic services in the United Kingdom (UK). The NHS offers healthcare free at the point of access. The guide describes how and when people with gender dysphoria should be referred; and what people with gender dysphoria can expect in terms of assessment, treatment, care and support from gender clinic services.
This report describes the findings from a study of how adults experience Attention-Deficit/Hyperactivity Disorder (ADHD). Qualitative interviews were carried out with 19 individuals to find out how the condition affected their lives. To date, there is a surprisingly small body of qualitative research on this issue internationally, and very little available from Ireland. Adults ranged from 18 to 53 years of age and were drawn from the Republic of Ireland and Northern Ireland.
If your interest in XXY is only that the second X is insignificant and that you are really an XY Male because you administer exogenous testosterone and by association, it makes you look more masculine, then there’s every possibility this book will not be of interest to you. If on the other hand, you have a keen interest in seeking answers as to what impact the second X might have on your wellbeing or what it is that makes us who we are, then you will most likely find this fascinating.
In 1961, Mary Frances Lyon proposed in Nature that one of the two X chromosomes in every cell of female mammals is inactivated. This, she argued, occurs to prevent XX female cells from expressing twice as many X-linked gene products as XY male cells.
Unlike other pediatric specialties, which usually started as offspring of internal medicine subspecialty development, medical genetics emerged from a basic science only one-half century ago. Scientists and physicians housed in a variety of basic science and clinical departments accomplished many of the major advances in the study of genetic diseases in children. In this article, we trace the development of medical genetics as a scientific and clinical discipline and concentrate on contributions of pediatricians or from departments of pediatrics.
Following is an opinion piece by Dr Michael Nobele XXY who was a champion advocate for XXY’s the world over, especially to those who struggled with making sense of their lives. This documented account was something that resonated with many and allowed them strength and courage to look beyond a doctor’s opinion and instead to charter their own course. As a community, we will always be grateful for such insight and as a tribute, we feel privileged to share it with you
May he rest in peace.
One Voice 47XXY
Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education.
The chromosome theory of inheritance is a cornerstone of modern genetics. It postulates that chromosomes are the carriers of Mendelian factors (genes) and are the physical basis of heredity. This theory, first proposed in 1903, led to the inseparable union of two previously distinct fields of investigation— cytological observation of chromosomes and genetic analysis of inheritance from breeding experiments. It was vital to subsequent rapid advances in genetics and the eventual understanding of the physical and chemical nature of genes.
This is a joint consensus statement by Australian and Aotearoa/New Zealand intersex organisations and independent advocates, in March 2017. It sets out the priorities and calls by the intersex human rights movement in our countries, under six headings: a preamble, human rights and legal reform; health and wellbeing; peer support; allies; and education, awareness and employment.
KS males present certain shared phenotypes such as small testes, tall stature, narrow shoulders, broad hips, sparse body hair, gynecomastia and decreased verbal intelligence. KS males also have increased risk of a wide range of additional disorders compared to the background population, i.e. comorbidities. Testicular dysfunction is prevalent in KS. It is estimated that KS causes 1–3% of all male infertility cases (5).
We consider this an excellent resource by Virginia Isaacs Cover MSW and we are especially grateful for her taking the time out from life to write it. This is the nitty-gritty of Sex Chromosome Variations filled to the rafters with information and experiences less spoken of. Certainly a book you’ll find difficult not to finish in one sitting.